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ANTI-HCV ACTIVITY OF ISATIN DERIVATIVES
| Compound code | EC50 (μg/ml) HCV RNA* | CC50 (μg/ml) Cell growth* | SI |
|---|---|---|---|
| 5CI-IS-AC | >50 | 50 | 0 |
| SPIII-5H | 19 | >50 | >2 |
| SPIII-5CI | >50 | >50 | 0 |
| SPIII-5BR | 17 | >50 | >3 |
| SPIII-5F | 6 | 42 | 7 |
| SPIII-5Me | >50 | >50 | 0 |
| SPIII-NA | >50 | >50 | 0 |
% untreted control. Interferon alfa-2b at 10.000 units/well reduced the signal in the viral RNA (luciferase) assay to background levels; without any cytostatic activity
