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. 2008 Jan-Feb;70(1):94–96. doi: 10.4103/0250-474X.40340

TABLE 1.

FACTORS TO BE CONSIDERED FOR TRANSDERMAL DOSE CALCULATION

Physiochemical Pharmacokinetic Biological

  • Solubility

  • Crystallinity

  • Molecular weight

  • Polarity

  • Melting point

  • Half-life

  • Volume of distribution

  • Total body clearance

  • Therapeutic plasma concentration

  • Bioavailable factor

  • Skin toxicity

  • Site of application

  • Allergic reactions

  • Skin metabolism

  • Skin permeability