TABLE 2.

IDEAL PROPERTIES OF DRUG CANDIDATE FOR TRANSDERMAL DRUG DELIVERY

Parameter	Properties
Dose	Should be low (<20 mg/day)
Half-life in h	10 or less
Molecular weight	<400
Partition coefficient	Log P (octanol-water) between-1.0 and 4
Skin permeability coefficient	>0.5 × 10−3 cm/h
Skin reaction	Non irritating and non-sensitizing
Oral bioavailability	Low
Therapeutic index	Low