Table 4.
Changes from baseline value in measures of efficacy of treatments for visceral leishmaniasis on day 21 (end of aminosidine treatment) and day 30 (end of sodium stibogluconate treatment) after start of treatment. Values are mean (SD) unless stated otherwise
| Aminosidine on day 21
|
Sodium stibogluconate 20 mg/kg/day (n=30)
|
Comparison (P value)*
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 12 mg/kg/day (n=30) | 16 mg/kg/day (n=30) | 20 mg/kg/day (n=30) | Day 21 | Day 30 | Day 21 | End of treatment | |||
| Body weight (kg) | 2.10 (1.82) | 2.40 (1.90) | 2.00 (1.57) | 2.03 (1.84) | 2.55 (1.82) | 0.82 | 0.60 | ||
| Fever (°C) | −1.64 (0.47) | −1.82 (0.60)† | −1.75 (0.42) | −1.33 (0.94)† | −1.46 (0.91) | 0.023 | 0.14 | ||
| Spleen size (cm) | −4.12 (1.91) | −4.75 (2.56)† | −5.1 (3.83)†‡ | −2.5 (2.57)† | −2.88 (3.12)‡ | 0.0032 | 0.023 | ||
| Haemoglobin concentration (g/l) | 17.9 (10.2) | 24.1 (16.1)† | 21.0 (8.9)† | 12.5 (12.6)† | 16.3 (15.8) | 0.003 | 0.11 | ||
| White cell count (109/l) | 3.05 (1.50)†‡ | 3.44 (1.48)†‡ | 3.12 (1.30)†‡ | 1.79 (1.48)† | 1.90 (1.85)‡ | 0.001 | 0.001 | ||
| Platelet count (109/l) | 110 (96) | 122 (74) | 142 (79)† | 82 (70)† | 100 (89) | 0.037 | 0.25 | ||
| Albumin concentration (g/l) | 9.1 (3.8)† | 8.9 (3.7)† | 9.8 (3.5)† | 5.8 (6.3)† | 7.8 (8.1) | 0.004 | 0.54 | ||
| Parasite burden (grade) | −2.07 (0.87)†‡ | −1.97 (0.93)†‡ | −2.30 (0.75)†‡ | −1.30 (0.91)† | −1.23 (1.14)‡ | 0.0002 | 0.002 | ||
*
Comparison between groups done by one way analysis of variance with post hoc Tukey’s honest significance difference.
†
Significant differences between groups on day 21.
‡
Significant differences between groups at end of treatment.