Table 1.
Metabolite and PG Concentrations Quantified by the LCmodel Spectral Fitting in the Rat Brain Under Three Anesthesia Conditions and Fitting Errors (n = 8)
| Metabolites | Isofluranea |
Low-PBa |
High-PBa |
|||
|---|---|---|---|---|---|---|
| Concentration | CRLB | Concentration | CRLB | Concentration | CRLB | |
| Asp | 3.21 ± 0.42 | 23 ± 9% | 2.82 ± 1.08 | 21 ± 7% | 3.22 ± 0.71 | 24 ± 14% |
| Cr | 3.53 ± 0.61 | 23 ± 15% | 3.23 ± 0.79 | 34 ±11% | 3.87 ± 0.42 | 22 ± 8% |
| GABA | 1.46 ± 0.55 | 25 ± 9% | 1.70 ± 0.30 | 20 ± 6% | 0.92 ± 0.36 | 52 ± 38% |
| GSH | 2.01 ± 0.25 | 11 ± 4% | 2.09 ± 0.49 | 13 ± 6% | 2.03 ± 0.32 | 21 ± 22% |
| Glc | 1.87 ± 0.61 | 29 ± 19% | 1.56 ± 0.52 | 33 ± 12% | 0.73 ± 0.47 | 174 ± 132% |
| Gln | 2.30 ± 0.42 | 17 ± 5% | 2.00 ± 0.71 | 20 ± 9% | 2.26 ± 0.59 | 19 ± 5% |
| Glu | 9.23 ± 0.96 | 4 ± 1% | 8.45 ± 0.86 | 5 ± 1% | 8.82 ± 1.33 | 10 ± 12% |
| Ins | 4.34 ± 0.64 | 8 ± 2% | 4.37 ± 0.24 | 11 ± 3% | 4.57 ± 0.76 | 11 ± 5% |
| Lac | 1.02 ± 0.62 | 25 ± 12% | 1.00 ± 0.69 | 33 ± 15% | 1.22 ± 0.67 | 29 ± 11% |
| NAA | 8.51 ± 0.29 | 4 ± 1% | 8.62 ± 0.90 | 4 ± 1% | 7.99 ± 1.02 | 4 ± 1% |
| PCr | 4.47 ± 0.61 | 8 ± 3% | 4.67 ± 0.83 | 6 ± 2% | 4.13 ± 0.42 | 9 ± 3% |
| PE | 2.66 ± 0.52 | 22 ± 15% | 3.26 ± 0.43 | 18 ± 10% | 3.01 ± 0.82 | 16 ± 7% |
| Taurine | 5.50 ± 0.43 | 6 ± 2% | 5.11 ± 0.84 | 7 ± 2% | 4.33 ± 0.40 | 10 ± 3% |
| GPC+PCho | 1.54 ± 0..71 | 18 ± 9% | 1.35 ± 0.42 | 21 ± 5% | 1.33 ± 0.36 | 21 ± 5% |
| PG | 1.60 ± 0.60 | 23 ± 10% | 6.01 ± 1.73 | 6 ± 2% | ||
a
The LCModel basis including metabolites and MM was applied to fit 1H MRS data from the rats anesthetized with isoflurane. The LCModel basis including metabolites, MM, and PG was applied to fit 1H MRS data from the rats anesthetized with pentobarbital.