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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Rev Med Virol. 2009 Nov;19(6):359–378. doi: 10.1002/rmv.630

Table 1.

Role of autophagy pathway and/or autophagy genes in protection against in vivo viral infection

Virus Autophagy
gene(s)		 Effect(s) on host-pathogen
interactions		 References
DNA viruses
Herpesviridae
HSV-1 beclin 1 Protects against lethal HSV-1 encephalitis in mice.
Antagonised by the viral ICP34.5 gene product		 [39]
RNA viruses
Alphaviridae
Sindbis virus beclin 1 Overexpressed Beclin 1 in virus infected cells of
the CNS protects mice from lethal Sindbis virus
encephalitis		 [32]
Tobamoviruses
Tobacco mosaic virus BECLIN 1, ATG3,
ATG7, VPS34 		Deletion of autophagy genes causes spread of
virus-induced hypersensitive response programmed
cell death to healthy tissue beyond site of viral
inoculation and increases viral replication at
inoculation site		 [44]
Rhabdoviridae
Vesicular stomatitis virus Atg8, Atg7, Atg12,
Atg18 		Deletion of autophagy genes increases viral replication
in Drosophila cell lines and decreases Drosophila survival		 [45]