Fig. 3.
ADT binomial test results. Dataset A: 204 samples. This displays a Manhattan plot of amplification distortion p-values (y-axis in a −log10 scale) along the genome (x-axis). Signals on chromosome 7 exceed the 3.61 genome-wide significance threshold, indicated by the horizontal line. Only two SNPs cross this threshold (rs1997375, rs10250847). The SNP rs10250847 passes certain quality control criteria and may motivate further biological investigation. The distribution of the ADT binomial test statistic is provided in a quantile–quantile (QQ) plot in Supplementary Figure 30.