TABLE 1.
Baseline clinical, biochemical and arterial blood gas profiles of patients with hepatopulmonary syndrome taking garlic (group 1) or placebo (group 2)
| Parameter | Group 1 (n=21) | Group 2 (n=20) | P |
|---|---|---|---|
| Age, years | 37.6±13.06 | 40.0±14.11 | 0.40 |
| Male:female, n | 17:4 | 18:2 | |
| Etiology, n | |||
| Alcoholic liver disease | 7 | 9 | |
| Chronic hepatitis B infection | 5 | 8 | |
| Chronic hepatitis C infection | 2 | – | |
| Autoimmune | 2 | 1 | |
| Wilson’s disease | 1 | – | |
| Cryptogenic | 4 | 2 | |
| Disease duration, years | 14.23±5.04 | 14.05±6.56 | 0.92 |
| Orthodeoxia, n | 14 | 12 | 0.91* |
| Cyanosis, n | 17 | 15 | 0.93* |
| Clubbing, n | 19 | 18 | 0.63* |
| Spider angioma, n | 3 | 5 | 0.64* |
| Alanine aminotransferase, U/mL | 56.27±25.47 | 63.63±41.36 | 0.60 |
| SO2, mmHg | 93.86±1.15 | 93.7±1.08 | 0.66 |
| PaO2, mmHg | 66.62±5.59 | 64.05±4.68 | 0.12 |
| P(A-a)O2, mmHg | 29.77±6.10 | 32.61±4.88 | 0.11 |
| MELD score | 14.58±5.28 | 15.75±6.94 | 0.59 |
| Child-Pugh score | |||
| Child’s class A | 3 | 4 | 0.94* |
| Child’s class B | 7 | 3 | 0.32* |
| Child’s class C | 11 | 13 | 0.62* |
Data presented as mean ± SD unless indicated otherwise.
*
Value calculated by χ2 test. MELD Model for End-Stage Liver Disease; P(A-a)O2 Alveolar-arterial oxygen gradient; PaO2 Partial pressure of oxygen in arterial blood; SO2 Oxygen saturation detected by pulse oximetry