Fig. 13.

MET-1 tumors in renal fat. NOD/SCID mouse inoculated with MET-1 cells. Fig. 13. HE. Fig. 13b. MET-1 tumors stained positive with a human-specific Ki67 antibody, which proved the human origin. Immunolabeling with mAb anti-human Ki67 and hematoxylin counterstain. Fig. 13c, d, and e. MET-1 cells strongly expressed matrix metalloproteinase 1 (MMP1), MMP2, and MMP3, respectively, in vivo (brown staining of cytoplasm). Immunolabeling with mAb anti-MMP1, anti-MMP2, and anti-MMP3, respectively, and hematoxylin counterstain. Fig. 13f. MET-1 cells weakly expressed MMP9. Immunolabeling with Ab anti-MMP9 and hematoxylin counterstain.