Table 4.

Altered expression of insulin and IGF polypeptide and receptor genes in PD and DLB

mRNA	CONTROL		PD		DLB
FRONTAL CORTEX
INR	0.006	±0.0003	0.003	±0.001	0.004	±0.001
IGF1R	28.97	±2.44	12.94	±4.925	3.31	±1.277**†
IGF2R	0.677	±0.048	0.553	±0.162	0.168	±0.059**†
Insulin	0.001	±0.0002	0.001	±0.0003	0.0004	±0.0002
IGF1	0.0002	±1E-05	0.001	±0.0001	0.0001	±3E-05
IGF2	3.3E-5	±2.1E-5	5.0E-5	±2.2E-5	0.00	±0.00
FRONTAL WHITE MATTER
INR	0.006	±0.0004	0.001	±0.0003***	0.001	±0.0004***
IGF1R	43.5	±8.315	2.648	±0.291***	2.72	±0.842***
IGF2R	0.395	±0.009	0.324	±0.129	0.401	±0.127
Insulin	0.001	±7E-05	3E-05	±1E-05***	2E-05	±9E-06***
IGF1	0.001	±0.0002	0.001	±0.0004	0.001	±0.0002
IGF2	0.0002	±0.00001	3.7E-6	±9.6E-7***	7.2E-6	±5.2E-6***
AMYGDALA
INR	0.0134	±0.002	0.005	±0.001**	0.004	±0.002**
IGF1R	2.437	±0.477	30.43	±11.87**	25.94	±7.56**
IGF2R	0.527	±0.105	0.979	±0.241***	1.839	±0.622***
Insulin	0.017	±0.002	0.005	±0.003**	0.003	±0.001**
IGF1	0.002	±0.0002	0.002	±0.001	0.002	±0.001
IGF2	0.0002	±0.0001	0.0002	±0.0001	0.0004	±0.0002
BASAL GANGLIA
INR	0.0007	±0.0001	0.0004	±0.0002	0.001	±0.0002
IGF1R	0.7054	±0.0668	0.6963	±0.095	0.959	±0.210
IGF2R	0.0301	±0.0035	0.0867	±0.0301	0.229	±0.102*
Insulin	8E-06	±3E-06	3E-06	±3E-06	4E-06	±2E-06
IGF1	0.0004	±3E-05	0.0003	±8E-05	0.0005	±0.0001
IGF2	0.000	±0.000	0.000	±0.000	0.000	±0.000

IN-insulin; IGF-insulin-like growth factor; R-receptor. Gene expression was measured by qRT-PCR analysis with values (×10⁻⁶) normalized to 18S rRNA measured in parallel reactions. Inter-group comparisons were made using repeated measures ANOVA with the post hoc Dunn's multiple comparison test.

^*P<0.05,

^**P<0.01,

^***P<0.005 relative to control;

^†P<0.05 or better relative to PD.