. Author manuscript; available in PMC: 2010 Apr 9.

Published in final edited form as: J Alzheimers Dis. 2009 Mar;16(3):585–599. doi: 10.3233/JAD-2009-0995

Table 5.

Altered neurotrophin and neurotrophin receptor expression in PD and DLB frontal cortex

mRNA	CONTROL		PD		DLB
TrkA	0.372	±0.041	0.185	±0.055	0.058	±0.017^***
TrkB	97.05	±15.36	108.3	±87.55	15.88	±5.794^**
p75^NGF	3.749	±0.945	3.056	±0.785	3.15	±0.979
BDNF	32.28	±3.203	10.48	±3.094^*	22.79	±4.254
NGF	25.3	±5.394	2.47	±0.436^***	6.63	±2.761^**

Trk-tyrosine kinase receptor; p75^NGF-low affinity NGF receptor; BDNF-brain derived neurotrophic factor; NGF-nerve growth factor. Gene expression was measured by qRT-PCR analysis with values (×10⁻⁹) normalized to 18S rRNA measured in parallel reactions. Inter-group comparisons were made using repeated measures ANOVA with the post hoc Dunn's multiple comparison test.

P<0.05,

^**

P<0.01,

^***

P<0.005 relative to control;

^†

P<0.05 or better relative to PD.