Figure 6.

Reduction in the overall attack rate with two drugs versus a single drug for: (a) unlimited, and (b) limited (1.8%) stockpile of zanamivir. The horizontal axis shows the ratio of the cumulative number of oseltamivir-resistance (TO_r) to the total number of infections (T_inf), when the switch to zanamivir occurs for different treatment levels displayed on the vertical axis. The solid (white) line corresponds to 54% treatment level (f_c) at which the overall attack rate is minimized for a single drug (oseltamivir).