Table 1. Compendium of the current literature on MX radiation damage.

Every effort has been made to make this compilation exhaustive: a copy is maintained and updated at the URL http://www.biop.ox.ac.uk/www/garman/gindex.html. References to the pre-1990 papers on RT MX damage studies can be found in §1.

Crystal-related questions
What is the minimum crystal size?	Gonzalez & Nave (1994 ▶), Teng & Moffat (2000 ▶), Glaeser et al. (2000 ▶), Sliz et al. (2003 ▶), Nave & Hill (2005 ▶), Cowan & Nave (2008 ▶), Moukhametzianov et al. (2008 ▶), Holton (2009 ▶), Holton & Frankel (2010 ▶)
What affects X-ray absorption? (and RADDOSE)	Murray et al. (2004 ▶, 2005 ▶), Kmetko et al. (2006 ▶), Holton (2007 ▶, 2009 ▶), Paithankar et al. (2009 ▶), Paithankar & Garman (2010 ▶)
Can the unit-cell expansion be used as a metric?	Teng & Moffat (2000 ▶), Murray & Garman (2002 ▶), Ravelli et al. (2002 ▶), Müller et al. (2002 ▶)
What is the effect of temperature (e.g. 100, 16, 40 K)?	Garman (1999 ▶), Hanson et al. (1999 ▶, 2002 ▶), Weik et al. (2001 ▶), Teng & Moffat (2002 ▶), Yano et al. (2005 ▶), Grablolle et al. (2006 ▶), Borek et al. (2007 ▶), Meents et al. (2007 ▶, 2010 ▶), Chinte et al. (2007 ▶), Corbett et al. (2007 ▶), Colletier et al. (2008 ▶)
Does the addition of radical scavengers increase dose tolerance?	Murray & Garman (2002 ▶), Betts (2004 ▶), Kauffmann et al. (2006 ▶), Borek et al. (2007 ▶), Southworth-Davies & Garman (2007 ▶), Holton (2007 ▶), Macedo et al. (2009 ▶), Barker et al. (2009 ▶), Nowak et al. (2009 ▶)
What are the susceptibilities of particular amino acids to specific damage and why?	Weik et al. (2000 ▶), Ravelli & McSweeney (2000 ▶), Burmeister (2000 ▶), Leiros et al. (2001 ▶), Fioravanti et al. (2007 ▶)
X-ray beam-related questions
What is the effect of changing the incident wavelength?	Arndt (1984 ▶), Gonzalez & Nave (1994 ▶), Murray et al. (2004 ▶), Weiss et al. (2005 ▶), Shimizu et al. (2007 ▶)
Is it beneficial to change/regulate the dose/dose-rate regime?	Teng & Moffat (2000 ▶), O’Neill et al. (2002 ▶), Sliz et al. (2003 ▶), Ravelli et al. (2002 ▶), Leiros et al. (2006 ▶), Owen et al. (2006 ▶), Howells et al. (2009 ▶)
What is the effect of the beam size compared with the crystal size?	Schulze-Briese et al. (2005 ▶)
Does the beam heat the crystal?	Kuzay et al. (2001 ▶), Nicholson et al. (2001 ▶), Müller et al. (2002 ▶), Snell et al. (2002 ▶, 2005 ▶, 2007 ▶), Kriminski et al. (2003 ▶), Mhaisekar et al. (2005 ▶)
Methods developments and applications
Development of convenient flux calibration of beamlines	Owen et al. (2009 ▶)
Development of on-line and off-line spectroscopy (UV–vis, Raman, XAS, EPR)	Weik et al. (2002 ▶), Murray & Garman (2002 ▶), Matsui et al. (2002 ▶), Takeda et al. (2004 ▶), Sato et al. (2004 ▶), Adam et al. (2004 ▶, 2009 ▶), Yano et al. (2005 ▶), Dubnovitsky et al. (2005 ▶), Carpentier et al. (2007 ▶), McGeehan et al. (2007 ▶, 2009 ▶), Pearson et al. (2007 ▶), Corbett et al. (2007 ▶), Holton (2007 ▶), Hough et al. (2008 ▶), Utschig et al. (2008 ▶), Owen et al. (2009 ▶)
Studying the effect on the success of MAD/SAD phasing	Rice et al. (2000 ▶), Schiltz et al. (2004 ▶), Zwart et al. (2004 ▶), González et al. (2005 ▶), González (2007 ▶), Ramagopal et al. (2005 ▶), Ravelli et al. (2005 ▶), Oliéric et al. (2007 ▶)
Development of RIP/RIPAS	Ravelli et al. (2003 ▶, 2005 ▶), Banumathi et al. (2004 ▶), Weiss et al. (2004 ▶), Nanao et al. (2005 ▶), Nanao & Ravelli (2006 ▶), Schiltz & Bricogne (2007 ▶), Rudiño-Piñera et al. (2007 ▶), Fütterer et al. (2008 ▶), Schönfeld et al. (2008 ▶)
Application/effect of radiation damage to/on the study of biological mechanisms	Matsui et al. (2002 ▶), Alphey et al. (2003 ▶), Nukaga et al. (2003 ▶), Mees et al. (2004 ▶), Takeda et al. (2004 ▶), Kort et al. (2004 ▶), Roberts et al. (2005 ▶), Dubnovitsky et al. (2005 ▶), Sjöblom et al. (2009 ▶), Adam et al. (2009 ▶)
Metalloproteins	Schlichting et al. (2000 ▶), Berglund et al. (2002 ▶), Adam et al. (2004 ▶), Baxter et al. (2004 ▶), Sato et al. (2004 ▶), Carugo & Djinovic Carugo (2005 ▶), Yano et al. (2005 ▶), Echalier et al. (2006 ▶), Pearson et al. (2007 ▶), Beitlich et al. (2007 ▶), Kühnel et al. (2007 ▶), Corbett et al. (2007 ▶), Hough et al. (2008 ▶), Petrova et al. (2009 ▶)
Phase transitions and/or radiation-induced changes with temperature-controlled cryocrystallography to study macromolecular function	Schlichting et al. (2000 ▶), Weik, Kryger et al. (2001 ▶), Weik, Ravelli et al. (2001 ▶), Weik et al. (2005 ▶), Hersleth et al. (2008 ▶), Colletier et al. (2008 ▶)
Software developments	Diederichs et al. (2003 ▶), Nanao et al. (2005 ▶), Bourenkov & Popov (2006 ▶, 2010 ▶), Diederichs (2006 ▶), Schiltz & Bricogne (2007 ▶)
Finding strategies to minimize radiation damage in data collections	Berglund et al. (2002 ▶), Adam et al. (2004 ▶), Stern et al. (2009 ▶), Incardona et al. (2009 ▶), Borek et al. (2010 ▶)
Extending the understanding of radiation damage in RT data collections	Southworth-Davies et al. (2007 ▶), Barker et al. (2009 ▶)
Studying RNA/DNA damage	Ennifar et al. (2002 ▶), Mees et al. (2004 ▶), Schiltz et al. (2004 ▶), Oliéric et al. (2007 ▶), McGeehan et al. (2007 ▶)