Figure 8. Impact of RAGE ligand on key stress signaling pathways in the absence of H/R in cardiomyocytes.

WT cardiomyocytes were incubated with CML-AGE (50 µg/ml) for different time points as indicated. Cells were lysed and subjected to Western blot analysis for the detection of phospho-JNK and total-JNK level (A), as well as phospho-S9-GSK3β and total- GSK3β (B). Data are representative of three independent experiments.