Table 2.
Number (%) of selected reports of trials of pharmaceutical and nonpharmaceutical treatments for hip and knee osteoarthritis that described items related to external validity
| Reporting of | All treatment | Pharmacologic treatment | Devices | Rehabilitation | Surgery |
|---|---|---|---|---|---|
| N (%) | N (%) | N (%) | N (%) | N (%) | |
| N=120 | N=30 | N=30 | N=30 | N=30 | |
| Recruitment | |||||
| – Method of recruitment | 43 (36) | 8 (27) | 13 (43) | 18 (60) | 4 (13) |
| – Specific method to enrich patient’s recruitment | 23 (19) | 18 (60) | 5 (17) | 0 | 0 |
| – Duration of recruitment (10 patients/month) | 56 (47) | 10 (33) | 11 (37) | 15 (50) | 20 (67) |
| Patients | |||||
| – Inclusion criteria | 118 (98) | 30 (100) | 30 (100) | 30 (100) | 28 (93) |
| – Exclusion criteria | 106 (88) | 30 (100) | 27 (90) | 28 (93) | 21 (70) |
| – Rate of strongly justified exclusion criteria in each article mean (SD) | 75.5 (23.6) | 77.7 (20.7) | 79.0 (21.3) | 66.9 (26.1) | 79.3 (25.6) |
| – Rate of potentially justified in each article mean (SD) | 1.5 (4.7) | 1.1 (3.4) | 1.5 (4.7) | 2.8 (6.8) | 0.5 (2.3) |
| – Rate of poorly justified in each article mean (SD) | 22.9 (23.0) | 21.3 (20.5) | 19.5 (19.4) | 30.3 (26.3) | 20.2 (25.3) |
| – Flow diagram | 48 (40) | 18 (60) | 11 (37) | 17 (57) | 2 (7) |
| – Number of eligible patients | 50 (42) | 12 (40) | 14 (47) | 21 (70) | 3 (10) |
| – Number of patients not meeting inclusion criteria | 39 (33) | 9 (30) | 8 (27) | 19 (63) | 3 (10) |
| – Number of patients refusing participation | 31 (26) | 6 (20) | 8 (27) | 14 (47) | 3 (10) |
| – Baseline characteristics of randomized patients | 109 (91) | 28 (93) | 28 (93) | 27 (90) | 26 (87) |
| - Age | 108 (90) | 28 (93) | 28 (93) | 27 (90) | 25 (83) |
| - Sex | 101 (84) | 27 (90) | 24 (80) | 25 (83) | 25 (83) |
| - Weight/body mass index | 74 (62) | 22 (73) | 18 (60) | 17 (57) | 17 (57) |
| - Ethnicity | 18 (15) | 8 (27) | 3 (10) | 5 (17) | 2 (7) |
| - Duration of disease | 47 (39) | 13 (43) | 20 (67) | 9 (3 0) | 5 (17) |
| - Measure of function status | 55 (46) | 17 (57) | 15 (50) | 16 (53) | 7 (23) |
| - Level of pain | 47 (39) | 14 (47) | 15 (50) | 15 (50) | 3 (10) |
| - Description of radiographic damage | 27 (23) | 5 (17) | 11 (37) | 4 (13) | 7 (23) |
| - NSAIDs/other drugs | 19 (16) | 6 (20) | 6 (20) | 6 (20) | 1 (3) |
| - Coexisting diseases | 14 (12) | 2 (7) | 1 (3) | 9 (30) | 2 (7) |
| Setting/center/care provider | |||||
| – Location of recruitment | 46 (38) | 9 (30) | 17 (57) | 17 (57) | 3 (10) |
| – Setting of recruitment | 40 (33) | 7 (23) | 16 (53) | 16 (53) | 1 (3) |
| – Country where the trial took place | 25 (21) | 8 (27) | 6 (20) | 10 (33) | 1 (3) |
| – Number of centers | 54 (45) | 19 (63) | 16 (53) | 15 (50) | 4 (13) |
| – Details of the centers | 24 (20) | 3 (10) | 10 (33) | 9 (30) | 2 (7) |
| – Number of patients recruited in each center | 0 | 0 | 0 | 0 | 0 |
| – Details of care provider | 35 (29) | 2 (7) | 6 (20) | 10 (33) | 17 (57) |
| – Number of care providers | 33 (28) | 2 (7) | 4 (13) | 7 (23) | 20 (67) |