Table 5.

Application of the risk scoring system to a hypothetical subject. Scoring weights are based on estimated coefficients from ‘final’ models, obtained using the saturated selection model, multiplied by 10 and rounded.

	Hypothetical subject	NP measures only		NP measures and demographics
		Scoring weight	Subject score and predicted status	Scoring weight	Subject score and predicted status
BRAAK stage
V/VI		35	0	36	0
Cerebral microinfarcts
≥ 3	Yes	23	23	21	21
Neocordical Lewy bodies
≥ 1		24	0	26	0
Cystic infarcts
≥ 1	Yes	11	11	15	15
Age (at death), years a	70			3	15
Birth year b	1934			2	68
Total score			34		119
Scoring thresholds c
Minimum sensitivity
70%		23	Dementia	125	No dementia
80%		11	Dementia	117	Dementia
90%		0	Dementia	107	Dementia
Minimum specificity
70%		23	Dementia	113	Dementia
80%		23	Dementia	117	Dementia
90%		34	Dementia	129	No dementia

^aMultiply scoring weight by number of years beyond age 65.

^bMultiply scoring weight by number of years beyond 1900.

^cSee manuscript text for actual sensitivity/specificity for each threshold