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. 2009 Aug 24;20(5):1164–1174. doi: 10.1093/cercor/bhp179

Figure 8.

Figure 8.

Schematic summary Figures illustrating trajectories of overall CB1R immunoreactivity and mRNA levels (A) and density of CB1R-IR axons in layers 1 and 4 (B) across development. Lines were generated by plotting the density as a percent of the maximum density value for individual animals for each marker as a function of age in months after conception on a log scale, fitted by Loess regression analysis, and smoothed by hand. The shaded area indicates the approximate age range corresponding to adolescence (15–42 months; Plant 1988) in macaque monkey. Note the different developmental time courses in overall CB1R immunoreactivity and mRNA levels (A) and in the laminar distribution of CB1R immunoreactivity (B).