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. 2009 Nov 10;20(5):1121–1130. doi: 10.1093/cercor/bhp184

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© 2009 The Authors

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — FF in freely moving adult rats is tightly associated with the successful induction of LTD. Evoked responses elicited by test-pulse stimulation (0.025 Hz) are significantly inhibited by application of the group II mGluR agonist DCG-IV (A, 20 ng, n = 21). Analogs show responses taken 30 min after treatment with vehicle (solid line) or DCG-IV (dashed line). Vertical scale bar: 2 mV; horizontal scale bar: 8 ms. (B). The maximal level of FF correlated significantly to the subsequent degree of synaptic depression. (C). LFS at 0.25 (n = 9), 0.3 (n = 7), or 0.5 Hz (n = 6) does not result in lasting synaptic depression at mossy fiber–CA3 synapses in the intact freely behaving rat. LFS at 1 Hz (D, n = 10) or 2 Hz (E, n = 9) significantly induces lasting depression (>24 h) of synaptic responses evoked at mossy fiber–CA3 synapses in the intact freely behaving rat (n = 10). LTD elicited by 2-Hz LFS is weaker and less stable than that elicited by 1-Hz LFS (P < 0.01). (F) Analogs represent responses obtained pre-LFS (i) and 5-min post-LFS (ii) using stimulation at 0.25, 0.3, and 0.5 Hz or (G) pre-LFS (i), 5 -in post-LFS (ii), and 24h post-LFS (iii) evoked using stimulation at 2 Hz. Vertical scale bar: 4 mV; horizontal scale bar: 8 ms.