Table 2.

Regions of brain activation at baseline

	Val/Val			Val/Met
Brain region	Vol	Mean z	x, y, z	Vol	Mean z	x, y, z
Left primary sensorimotor cortex, premotor cortex, SMA	13 134	6.34	−30, −12, 68	5095	4.24	−8, −16, 64
Left cerebellum	1701	5.76	−30, −62, −28	487	4.6	−34, −54, −38
Right cerebellum	3645	6	24, −50, −30	694	4.12	22, −56, −32
Right inferior parietal lobule	905	4.3	56, −42, 30	391	4.11	64, −36, 30
Left thalamus, ventral posteromedial nucleus	96	4.02	−14, −20, 6
Right thalamus, ventrolateral nucleus	695	5.64	14, −14, 4
Left striatum	448	5.5	−26, −2, 6
Right striatum	311	4.34	20, 4, 4
Right dorsolateral prefrontal cortex	862	4.35	38, 40, 30
Left inferior parietal lobule				556	4.23	−34, −68, 54
Right motor cortex				117	3.79	50, −4, 50
Left cingulate motor area				43	3.59	−8, −24, 50
Left superior parietal lobule				118	3.28	−28, −48, 62
Left midbrain				117	3.54	−8, −14, −18

Note: Vol = volume of cluster, reported in voxels (8 mm³ each); mean z = mean z-score for the peak voxel within each cluster; x, y, z are reported in MNI coordinates. Results are the regions of significant activation in each group, in the whole-brain analysis, from separate 1-sample t-tests performed on each genotype group at P < 0.001, uncorrected for multiple comparisons, at baseline. In addition to above, note that the Val/Val group also showed significant activation in left superior temporal gyrus, right middle temporal gyrus, and the left occipital lobe, whereas the Val/Met group also showed significant activation in bilateral superior temporal gyri.