Table 3.

Brain areas where change over time differed as a function of genotype

Brain region	Which genotype group accounted for finding	Vol	Mean z	x, y, z
Right sensorimotor cortex (medial edge)	Val/Val expansion	269	3.37	26, −28, 48
Left sensorimotor cortex (medial edge)	Val/Val expansion	210	3.25	−20, −36, 46
Left medial frontal cortex	Val/Val expansion and Val/Met reduction	182	3.61	−8, 36, 46
Left superior temporal gyrus anteriorly	Val/Val expansion and Val/Met reduction	180	3.37	−54, −4, −12
Left superior temporal gyrus posteriorly	Val/Met reduction	209	3.48	−46, −60, 6

Note: Table 3 lists the brain areas in which the change in activation volume over time differed between the 2 genotype groups, based on the time × group interaction map. Review of the parameter estimates (beta values) within each of these brain regions provided insight as to which genotype groups accounted for the observed differences. Vol = volume of cluster, reported in voxels (8 mm³ each); mean z = mean z-score for the peak voxel within each cluster; x, y, z are reported in MNI coordinates.