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. Author manuscript; available in PMC: 2011 Mar 24.
Published in final edited form as: J Am Chem Soc. 2010 Mar 24;132(11):3793–3807. doi: 10.1021/ja909371t

Table 1.

Dependence of fluorination yield on reaction conditions

entry solvent temperature yield [%] 4 : 13a)
1 pyridine 50 ºC <1:50
2 75 ºC <1:57
3 100 ºC <1:72
4 DMSO 50 ºC 38:60
5 75 ºC 48:50
6 100 ºC 66:32
7 150 ºC 97:1
8 chloroform 50 ºC 54:44
9 75 ºC 64:33
10 100 ºC 70:27
11 neat 75 ºC 95:<1
12 100 ºC 97:<1
13 150 ºC 98:<1
a)

Yield determined by 1H and 19F NMR using an internal standard.