Figure 2.

Collagen-embedded HA does not alter polymerization of a collagen matrix. MDA-MB-231 cells were grown on type I collagen gels were prepared as described in Figure 1 for 2 hours and visualized by scanning electron microscopy. (A and B) Collagen gels were visualized by SEM in the presence of eHA (B and B′) or collagen alone (A and A′). Scale bars are 2 µm for (A and B) and 1 µm for (A′ and B′). (C and D) Cells growing on collagen alone (C and C′) or in the presence of eHA (D and D′) were visualized with SEM. Scale bars are 20 µm for (C and D) and 4 µm for (C′ and D′).