Figure 1.

(A and B) Spectral karyotyping (SKY) of a lung adenocarcinoma showing numerous numerical and structural chromosome changes. The inverted-DAPI image is shown in (A) and the classified image with the pseudo-colors is shown in (B). The specimen was near-diploid, with rearrangements involving most chromosomes. In translocations, the origin of the material is listed on the right of the chromosomes. (C) Summary of genomic imbalances reported in lung cancer (reviewed in ref. 11). Small cell lung cancer (SCLC) is represented on the left of the chromosome idiograms, non-small cell lung cancer (NSCLC) is represented on the right. Copy number gain is represented by red bars, focal amplification by red dots and copy number loss by blue bars.