Table 2.
Motor and sensory nerve conduction velocities in normal chow and high fat diet-fed mice maintained with and without PMI-5011 treatment.
| Groups | NC | NC + T | HFD | HFD + T |
|---|---|---|---|---|
| Variables | ||||
| Baseline (prior to the beginning of HFD feeding) | ||||
|
| ||||
| MNCV, ms−1 | 50.8 ± 0.75 | |||
| SNCV, ms−1 | 38.4 ± 0.71 | |||
|
| ||||
| 16-wk time point (prior to PMI-5011 treatment) | ||||
|
| ||||
| MNCV, ms−1 | 51.8 ± 0.87 | 46.3 ± 0.77** | ||
| SNCV, ms−1 | 39.1 ± 0.65 | 33.8 ± 0.81** | ||
|
| ||||
| 23-wk time point (final measurements) | ||||
|
| ||||
| MNCV, ms−1 | 51.4 ± 1.78 | 52.3 ± 2.14 | 45.9 ± 1.18* | 51.0 ± 1.45§,# |
| SNCV, ms−1 | 38.7 ± 0.92 | 37.3 ± 1.08 | 33.6 ± 1.14** | 36.8 ± 0.92§,£,# |
Data are expressed as Mean ± SEM, n = 10–12 per group. NC: normal chow; T: treatment; HFD: high fat diet; MNCV: motor nerve conduction velocity; SNCV: sensory nerve conduction velocity. *,**P < .05 and < .01 versus mice fed NC; § P < .05 versus the baseline value (16-wk time point); £ P < .05 versus mice fed NC (16-wk time point); # P < .05 versus untreated mice fed HFD (23-wk time point).