Table 3.

Variables of small sensory fiber neuropathy in normal chow and high fat diet-fed mice maintained with and without PMI-5011 treatment.

Groups	NC	NC + T	HFD	HFD + T
Variables
Baseline (prior to the beginning of HFD feeding)
Paw withdrawal latency, s−1	8.8 ± 0.15
Tail flick response latency, s−1	2.41 ± 0.08
Tactile withdrawal threshold, g	1.76 ± 0.12
Mechanical withdrawal threshold, g	11.5 ± 0.31
16-wk time point (prior to PMI-5011 treatment)
Paw withdrawal latency, s−1	8.2 ± 0.17		13.0 ± 0.31**
Tail flick response latency, s−1	2.48 ± 0.09		4.62 ± 0.13**
Tactile withdrawal threshold, g	1.72 ± 0.13		1.06 ± 0.09**
Mechanical withdrawal threshold, g	10.6 ± 0.28		13.3 ± 0.24**
23-wk time point (final measurements)
Paw withdrawal latency, s−1	9.1 ± 0.32	10.3 ± 0.41	15.7 ± 1.14**	11.4 ± 0.68§,∗,##
Tail flick response latency, s−1	2.29 ± 0.11	2.52 ± 0.10	4.07 ± 0.15**	2.59 ± 0.10§§,##
Tactile withdrawal threshold, g	1.52 ± 0.21	1.45 ± 0.16	0.76 ± 0.03**	1.20 ± 0.08££,#
Mechanical withdrawal threshold, g	11.2 ± 0.46	11.2 ± 0.36	15.2 ± 0.10**	12.3 ± 0.59£,##

Data are expressed as Mean ± SEM, n = 10–12 per group. NC: normal chow; T: treatment; HFD: high fat diet; *^,**P < .05 and < .01 versus corresponding controls; ^§,§§ P < .05 and < .01 versus the baseline value (16-wk time point); ^£,££ P < .05 and < .01 versus mice fed NC (16-wk time point); ^#,## P < .05 and < .01 versus untreated mice fed HFD (23-wk time point).