Table 3. Relationship of BPDE-like DNA adduct levels and CYPA1 and GSTM1 polymorphisms in pterygium patients.
|
|
BPDE-like DNA adduct levels |
|
|
|---|---|---|---|
| Gene | Negative | Positive | p value |
|
CYP1A1 | |||
| A |
29 |
5 |
|
| B |
29 |
25 |
|
| C |
11 |
4 |
0.006 |
|
GSTM1 | |||
| Null |
17 |
17 |
|
| Present | 25 | 44 | 0.205 |
The results were evaluated independently by three observers and scored for the percentage of positive nuclei: negative, 0%; positive, more than 11% positive cells. BPDE DNA adducts analyzed in this study are based on prior pterygium samples [25].