Figure 3.
Changes in diameter of the basilar artery in response to arachidonic acid (upper left panel) and acetylcholine (lower left panel) in non-Tg and Gpx1 Tg mice. Effects of hydrogen peroxide on vessel diameter in non-Tg mice (upper middle panel) and in non-Tg and Gpx1 Tg mice (upper right panel). Vascular responses to papaverine and KCl are also shown (lower middle panel and lower right panel, respectively). In non-Tg and Gpx1 Tg mice respectively, vessel diameter was 131±4 and 130±5 µm under baseline conditions and 92±4 and 91±4 µm after preconstriction with U46619. Values are means±SE. * = P<0.05 versus non-Tg mice unless otherwise noted.
