Figure 5.

Thrombus size, distribution, and drug transport characteristics impact arterial drug deposition and distribution without altering drug release kinetics. (A) Fractional drug release from the stent (Note: all curves with and without thrombus overlap) (B) Average arterial drug concentration resulting from focal and diffuse thrombus (C) Axial arterial drug distribution in the presence of focal and diffuse thrombus 1 day after implantation at a depth of 10 um into the arterial wall, (D) Average arterial drug concentration resulting from two extremes in thrombus drug transport properties, which represent different thrombi compositions. (Note: For all these cases, the arterial drug diffusivity in the transmural direction (D_r) was 10 um²/s and in the axial direction (D_z) was 1 um²/s; the drug diffusivity within the stent coating (D_c) was 1e-5 um²/s. Strut width was 150 um.)