Figure 7.

Thrombus slows drug release kinetics when drug release occurs rapidly over minutes to hours, which is faster than the typical release rate achieved by intravascular stents. Subsequently, thrombus increases local drug availability leading to elevated arterial drug levels. (A) Fractional release of drug from the stent, (B) Average arterial drug concentration. The arterial drug diffusivity in the transmural direction (D_r) was 10 um²/s and in the axial direction (D_z) was 1 um²/s; the drug diffusivity within the stent coating was 10 um²/s; drug diffusivity within the mural thrombus was 20 um²/s. (Note: black curve = without thrombus, pink curve= with focal thrombus 0.1 mm²; Strut width and height = 150 um. (A) and (B) are plotted on different time scales on the x-axis)