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Tissue loading in the saturable binding regime. The predicted concentration dependence of drug uptake from bulk solutions of rapamycin (black), paclitaxel (dark grey) or heparin (light grey). Tissue associated drug at 1 h is normalized to the corresponding equilibrium uptake and plotted versus the normalized concentration of bulk drug. Numerically simulated loadings (lines) are contrasted with the super‐threshold approximations (eqn 25, solid triangles).
