Table I.
Effect of aqueous extract of Andrographis paniculata (200 mg/kg) on serum creatinine, serum urea, blood urea nitrogen levels and urine volume in gentamicin-induced nephrotoxic rats.
| Groups | Serum creatinine (µmol/L) | Serum urea (mmol/L) | Blood urea nitrogen (mmol/L) | Urine volume (L) |
|---|---|---|---|---|
| Normal | 57.46±0.01 | 5.25±1.03 | 6.89±1.40 | 2.58×10−3±0.11 |
| Gentamicin control (80 mg/kg, i.p.) | 170.61±0.30a (196.92) | 11.64±0.43b (121.96) | 23.54±0.63b (241.65) | 5.32×10−3±0.20b (106.20) |
| Extract-treated (200 mg/kg, p.o.) | 68.95±0.10c (20.00) | 6.07±0.32d (15.69) | 9.56±0.16d (38.75) | 2.98×10−3±0.50c (15.50) |
| Statistics (one-way ANOVA) | F=15.607 (P<0.001) | F=44.690 (P<0.001) | F=42.977 (P<0.001) | F=23.622 (P<0.001) |
Values are mean±SE (n=5). Data for normal animals are considered as base-line data; there was no significant base-line difference between the groups. Percentage increase (in parentheses) is calculated with reference to normal control.
aP<0.01 versus control group.
bP<0.001 versus control group.
cP<0.01 versus gentamicin group.
dP<0.001 versus gentamicin group.