Table 7.
Meta-analysis of data from individual patients. Effect of prophylactic topical antibiotics on mortality in patients in intensive care
| APACHE II score | No of studies | No treated | No of controls | Odds ratio (95% CI) |
|---|---|---|---|---|
| Medical patients | ||||
| 0-14 | 8 | 18/108 | 19/117 | 0.99 (0.47 to 2.06) |
| 15-29 | 6 | 77/205 | 77/232 | 1.08 (0.72 to 1.62) |
| ⩾30 | 9 | 15/29 | 13/23 | 1.09 (0.32 to 3.68) |
| Total | 104/342 | 109/372 | 1.06 (0.75 to 1.49) | |
| Surgical patients | ||||
| 0-14 | 8 | 10/48 | 11/57 | 1.25 (0.44 to 3.53) |
| 15-29 | 9 | 18/64 | 15/63 | 1.18 (0.52 to 2.70) |
| ⩾30 | 9 | 2/6 | 3/4 | 0.46 (0.04 to 5.27) |
| Total | 30/118 | 29/124 | 1.13 (0.61 to 2.12) | |
| Trauma patients | ||||
| 0-14 | 12 | 17/238 | 19/303 | 1.20 (0.59 to 2.46) |
| 15-29 | 11 | 36/231 | 54/312 | 0.84 (0.52 to 1.34) |
| ⩾30 | 12 | 4/8 | 6/12 | 1.17 (0.10 to 13.26) |
| Total | 57/477 | 79/627 | 0.94 (0.64 to 1.39) | |
| Overall | 191/937 | 217/1123 | 1.02 (0.81 to 1.30) |