Table 2.
Genotype and allele frequencies of NOD2/CARD15 polymorphisms in childhood-onset CD patients, adult-onset CD, and controls n (%)
| Childhood-onset CD (n = 110) | Adult-onset CD (n = 364) | Controls (n = 539) | |
| R702W | |||
| Genotype | |||
| CC | 94 (85.45) | 300 (82.40) | 482 (89.40) |
| CT | 14 (12.72) | 62 (17.00) | 55 (10.20) |
| TT | 2 (1.81) | 2 (0.55) | 2 (0.37) |
| P value1 | NS | ||
| P value2 | NS | ||
| P value3 | 0.0260 | ||
| T allele | 18 (8.18) | 66 (9.10) | 59 (5.47) |
| P value1, OR (95% CI) | NS | ||
| P value2, OR (95% CI) | NS | ||
| P value3, OR (95% CI) | 0.0040, 1.72 (1.19-2.48) | ||
| G908R | |||
| Genotype | |||
| GG | 91 (82.73) | 295 (81.00) | 468 (86.83) |
| GC | 17 (15.45) | 65 (18.00) | 69 (12.80) |
| CC | 2 (1.81) | 4 (1.00) | 2 (0.37) |
| P value1 | NS | ||
| P value2 | NS | ||
| P value3 | 0.0420 | ||
| C allele | 21 (9.54) | 73 (10.00) | 73 (6.77) |
| P value1, OR (95% CI) | NS | ||
| P value2, OR (95% CI) | NS | ||
| P value3, OR (95% CI) | 0.0140, 1.53 (1.09-2.15) | ||
| 3020insC | |||
| Genotype | |||
| - | 78 (70.90) | 301 (82.69) | 503 (93.32) |
| insC/- | 28 (25.45) | 57 (15.66) | 35 (6.49) |
| insC/insC | 4 (3.64) | 6 (1.65) | 1 (0.18) |
| P value1 | < 0.0001 | ||
| P value2 | 0.0200 | ||
| P value3 | < 0.0001 | ||
| insC allele | 36 (16.36) | 69 (9.47) | 37 (3.43) |
| P value1, OR (95% CI) | < 0.0001, 5.5 (3.39-8.94) | ||
| P value2, OR (95% CI) | 0.0067, 1.87 (1.21-2.88) | ||
| P value3, OR (95% CI) | < 0.0001, 2.95 (2.04-4.44) |
1
Childhood-onset vs controls;
2
Childhood-onset vs adult onset;
3
Adult onset vs controls. NS: Not significant.