Table 3.
Genotype and allele frequencies of ATG16L1 polymorphism rs2241880 and IL23R polymorphism rs11209026 in childhood-onset CD patients, adult-onset CD, and controls n (%)
| Childhood-onset CD (n = 110) | Adult-onset CD (n = 364) | Controls (n = 539) | |
| rs2241880 | |||
| Genotype | |||
| AA | 17 (15.45) | 46 (12.64) | 104 (19.30) |
| AG | 45 (40.91) | 177 (48.63) | 274 (50.83) |
| GG | 48 (43.64) | 141 (38.74) | 161 (29.90) |
| P value1 | 0.0190 | ||
| P value2 | NS | ||
| P value3 | 0.0040 | ||
| G allele | 141 (64.09) | 459 (63.05) | 596 (55.29) |
| P value1, OR (95% CI) | 0.0170, 1.44 (1.07-1.95) | ||
| P value2, OR (95% CI) | NS | ||
| P value3, OR (95% CI) | 0.0010, 1.38 (1.14-1.67) | ||
| rs11209026 | |||
| Genotype | |||
| RR | 105 (95.45) | 329 (90.38) | 458 (84.97) |
| RQ | 5 (4.54) | 32 (8.79) | 79 (14.66) |
| 0 | 3 (0.82) | 2 (0.37) | |
| P value1 | 0.0120 | ||
| P value2 | NS | ||
| P value3 | 0.0220 | ||
| Q allele | 5 (2.27) | 38 (5.22) | 83 (7.69) |
| P value1, OR (95% CI) | 0.0018, 0.28 (0.11-0.69) | ||
| P value2, OR (95% CI) | NS | ||
| P value3, OR (95% CI) | 0.0400, 0.66 (0.44-0.98) |
1
Childhood-onset vs controls;
2
Childhood-onset vs adult onset;
3
Adult onset vs controls.