Table 4. Comparison of protein and transcript expression.
Since both profiling techniques utilized different comparison criteria, the fold changes represented below have been calculated using the mean value of the normalized expression intensities. Table (A) shows overall expression during preterm labor inclusive of all subgroups. Table (B) shows expression in each subgroup.
| A | Protein/Gene Name | 2 DE Fold Change | Microarray Fold Change |
|---|---|---|---|
| PGRMC2/PGRMC2 | 1.6* | 1.1 | |
| PDI/PDIA2 | 1.5* | 1.3 | |
| Annexin 3/ANXA3 | 3* | 1.3 | |
| Annexin 5/ANXA5 | 2.6* | 2 | |
| Osteoglycin/OGN | 2.3* | 1.2 | |
| Galectin 1/LGALS1 | 2.4* | 0.9 |
| B | Protein/Gene Name | PPL | IPL | APL | |
|---|---|---|---|---|---|
| PGRMC2/PGRMC2 | Protein | 1.8* | 1.5 | 1.4 | |
| mRNA | 1 | 1 | 1.1 | ||
| PDI/PDIA2 | Protein | 1.6* | 1.3 | 1.7 | |
| mRNA | 1.3 | 1.7 | 1.2 | ||
| Annexin 3/ANXA3 | Protein | 2.9* | 2.7* | 3.7* | |
| mRNA | 1.2 | 1.6 | 1.3 | ||
| Annexin 5/ANXA5 | Protein | 2.2 | 3* | 2.5 | |
| mRNA | 1.2 | 2.9* | 1 | ||
| Osteoglycin/ | Protein | 2* | 2.3 | 2.8 | |
| mRNA | 0.7 | 0.9 | 2.1 | ||
| Galectin 1/ | Protein | 2.3* | 2 | 3.4* | |
| mRNA | 1 | 0.9 | 0.9 |
Abbreviations: PPL = Pure Preterm-in-labor, IPL = Infection Preterm-in-labor, APL = Abruption Preterm-in-labor.
*
Statistically significant expression (p<0.05) as determined by 2DGE analysis software.