Table 2.
Blood and serum chemistry profiles of the AAV1-FS344–treated macaques. Hematology and serum chemistries were monitored throughout the study monthly after gene transfer with CMV-FS and MCK-FS. Data from 5 and 15 months are shown. The values are means ± SD (n = 3); there were no significant changes at any time. CK, creatine kinase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; GGT, γ-glutamyltranspeptidase.
| MCK-FS |
CMV-FS |
|||||
|---|---|---|---|---|---|---|
| Baseline | 5 Months after injection | 15 Months after injection | Baseline | 5 Months after injection | 15 Months after injection | |
| Hemoglobin (mg/dl) | 11.7 ± 1.2 | 12.3 ± 0.7 | 13.5 | 12.9 ± 0.9 | 12.9 ± 0.3 | 12.6 |
| Leukocytes (103/mm3) | 9.4 ± 3.6 | 11.0 ± 1.8 | 7.5 | 13.2 ± 1.7 | 10.8 ± 2.8 | 15.5 |
| Platelets (103/mm3) | 444.7 ± 78.6 | 473.7 ± 101.5 | 448.5 | 475.3 ± 21.2 | 470.0 ± 10.8 | 432.0 |
| CK (U/liter) | 282.3 ± 123.3 | 103.3 ± 34.0 | 261.0 | 315.1 ± 436.8 | — | 141.0 |
| ALT (U/liter) | 29.7 ± 12.9 | 19.7 ± 2.1 | 31.5 | 28.7 ± 10.3 | 21.7 ± 4.6 | 29.5 |
| AST (U/liter) | 35.3 ± 3.51 | 34.7 ± 9.9 | 37.5 | 44.3 ± 11.4 | 31.7 ± 6.0 | 35.5 |
| BUN (mg/dl) | 19.0 ± 1.0 | 12.3 ± 1.5 | 16.0 | 16.3 ± 4.9 | 16.0 ± 4.4 | 18.0 |
| Creatinine (mg/dl) | 0.5 ± 0.1 | 0.8 ± 0.1 | 0.7 | 0.9 ± 0.2 | 0.9 ± 0.1 | 0.9 |
| GGT (U/liter) | 72.0 ± 28.8 | 92.0 ± 38.7 | 77.5 | 77.0 ± 20.7 | 71.3 ± 18.2 | 75.0 |