Skip to main content
. Author manuscript; available in PMC: 2010 Apr 12.
Published in final edited form as: Biochemistry. 2008 Jul 24;47(33):8648–8655. doi: 10.1021/bi800635y

Figure 1.

Figure 1

The proposed mechanism of U3S catalyzed formation of uro’gen III (3). This figure resembles that of Roessner et al. (33). Spirolactam, a transition state mimic, has been shown to be a competitive inhibitor of U3S (36), and the structure of a synthetic precursor, methylated dinitrilepyrrolenine, has been determined (6). A = CH2CO2, P = CH2CH2CO2.