Table 1.

Absolute RhEpo levels measured in serum at key time-points before and after rapamycin administration ^*

Time	RhEpo (mU/ml)
Pre-vector (n=6)	2.8 ± 0.6
Low dose (n=3)	Before	After
Day 28	0.4 ± 0.2	0.6 ± 0.3
Day 42	1.3 ± 0.7	0.7 ± 0.4
Day 56	1.2 ± 0.1	0.9 ± 0.2
Day 70	0.9 ± 0.4	1.9 ± 1.1
Days 84–98**	0.9 ± 0.5	1.9 ± 1.1
High dose (n=2 or 3 #)	Before	After
Day 28	1.4 ± 0.3	1.4 ± 0.5
Day 42	1.2 ± 0.5	0.9 ± 0.6
Day 56	2.8 ± 0.7	6.2 ± 4.7
Day 70	2.3 ± 0.5	1.5 ± 1.0
Day 84	2.6 ± 0.8	3.4 ± 2.1

^*The data shown are absolute values of rhesus erythropoietin (RhEpo) determined in serum by ELISAs for key time-points studied. Baseline values for all six macaques are shown as “Pre-vector”. Thereafter, animals received either dose of vector (1.5×10¹¹ or 1.5×10¹² vg/gland) and rapamycin at the indicated times. Data shown are mean values ± SE for the number (n) of animals. A graphic representation of these data (ratio of RhEpo after/RhEpo before rapamycin) can be found in Figure 3B. Rapamycin was administered at 0.1 mg/kg for Days 28–70, and 0.5 mg/kg for the last time-point.

^**Two animals received rapamycin on day 84 and one on day 98 (see text).

^#One high dose animal (6851) was euthanized after day 56.