Table 4.

Key serum chemistry and hematology values from macaque #6851 ^*

	Day of sampling
	Pre (−14)	15	29	43	56**
Alb	4.2	3.8	3.7	2.6	2.3
SGPT	113	59	66	34	37
ALP	145	139	140	233	380
BUN	18	15	16	14	11
Na	142	143	143	138	146
K	4.5	3.4	3.5	3.5	3.5
Cl	106	104	106	102	97
WBC	4.03	9.11	4.11	14.04	18.68
HCT	39.2	37	37.5	31.9	29
Platelets	153	173	167	415	13
Lymphocytes	36.2	15.1	34.5	13.5	9.2

^*The data shown are representative clinical laboratory values obtained for animal #6851 from the high dose group. This animal experienced a severe adverse event, interstitial pneumonia in the left lung. Sodium (Na), potassium (K) and chloride (Cl) are as mEq/L; blood urea nitrogen (BUN) as mmol/L; serum glutamic pyruvic aminotransferase (SGPT) as U/L; alkaline phosphatase (ALP) as U/L; albumin (Alb) as g/dL; white blood cell (WBC) count as cells/mm³; hematocrit (HCT) as percent; platelet count as ×10³/mm³; lymphocytes as percent.

^**Day 56 is when the last rapamycin dose was given to this macaque (see Table 1, Figure 3).