FIGURE 2.

Ceramide generation following UV-C irradiation is dependent on BAK/BAX. WT and DKO BMK cells were left untreated or UV-C irradiated (10 mJ/cm²). a, total ceramides; b, long-chain ceramides; and c, very long-chain ceramides were measured, normalized to total lipid phosphate, and expressed relative to their corresponding untreated control cells. Data are the mean of three independent experiments. Error bars, ±S.D. For statistical analyses a two-way ANOVA was performed with a Bonferroni post-test. *, p ≤ 0.05 statistically significant difference between treatment and its corresponding control and #, p ≤ 0.05 statistically significant difference between DKO and the corresponding time-matched WT value.