. 2010 Feb 22;285(16):11931–11936. doi: 10.1074/jbc.M109.058859

TABLE 1.

Immunoreactivity of mAbs to native or denatured scrapie-affected mouse brain homogenates

Immunoreactivities of mAbs to native homogenate (−Gdn, guanidine-untreated) and to denatured homogenate (+Gdn, guanidine-treated were compared (n = 3). The mAbs obtained showed stronger immunoreactivity to −Gdn antigen than to +Gdn antigen, whereas mAb T2 yielded a contrasting result. Values between −Gdn and +Gdn are significantly different.

mAb	A₄₅₀ (means ± S.E.)
mAb	−Gdn	+Gdn
3B7	0.686 ± 0.061	0.421 ± 0.056^a
3H6	1.017 ± 0.017	0.104 ± 0.011^b
2C4	1.362 ± 0.077	0.404 ± 0.092^b
1B12	0.643 ± 0.202	0.127 ± 0.003^c
T2	0.963 ± 0.040	1.939 ± 0.004^b

^ap < 0.01.

^b p < 0.001.

^cp < 0.05.