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Hypotheses of the lineage of renin-containing cell. A, shown is a traditional hypothesis. The JG cell (Renin-containing cell) is hypothesized to be derived from the vascular smooth muscle cell (VSMC) through metaplastic transformation. B, shown is a new hypothesis. Renin progenitor cell may exist, and the renin-containing cell can give rise to vascular smooth muscle cells. The MSC may be the origin of renin-containing cell.
