FIGURE 3.

Overlapping binding sites and C-terminal rearrangement of aldolase. A, stereo view of the overlapping binding sites for aldolase substrate (FBP; pale blue) and the LC4 domain of SNX9 (cyan and gray) indicate a competition between the LC4 peptide and FBP. B, stereo representation of the C-terminal region of aldolase depending on the type of ligand bound in the same orientation as shown in Fig. 1B. The substrate FBP (pale blue) accommodates the C terminus in the active site, whereas the LC4 peptide (wheat and pink) precludes FBP binding and the intramolecular active site-C terminus interaction.