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. 2010 Jan 22;285(16):11991–11997. doi: 10.1074/jbc.M109.066621

FIGURE 1.

FIGURE 1.

Inhibition of mTORC2 with rapamycin pretreatment or siRNA blocks EC migration toward VEGF (10 ng/ml). A, migration of HUVECs and HCAECs following treatment with rapamycin (RPM; 100 nmol/liter) or paclitaxel (PTX; 10 nmol/liter) for the indicated time. B, migration of HUVECs and HCAECs following 48 h of treatment with the indicated doses of rapamycin. C, transfection with siRNA targeting rictor and raptor significantly reduces the target protein in HCAECs compared with nontargeting (NT) siRNA. D, migration of HCAECs following pretreatment with raptor, rictor, or nontargeting siRNA. † and ‡, p < 0.01 and p < 0.05, respectively, compared with the control. Error bars represent the mean ± S.E. (n = 3). WB, Western blot.