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. 2010 Feb 23;285(16):12096–12100. doi: 10.1074/jbc.M109.063305

FIGURE 1.

FIGURE 1.

Schematic overview of the selection and maturation process. The red X indicates the amino acid position that was randomized in a given library. The terms Primary lib and mat lib refer to primary and maturation libraries, respectively. The sequences of CTLD libraries used as a basis for the next round of selection are shown in bold. a, amino acids maintained from the primary clone to TN-2-B-1-C31. b, amino acids maintained from the first round maturation clone to TN-2-B-1-C31. c, amino acids maintained from the second round maturation clone to TN-2-B1-C31.