FIGURE 10.

Selective competition of ligands by sortilin-derived peptide antagonist. SPR binding analysis of 50 nm unprocessed pro-BDNF (A), 50 nm unprocessed pro-NGF (B), and 90 nm RAP (C) to immobilized sortilin in the absence and presence of the sort166–181 peptide (100 μm). Specific inhibition of pro-NGF and pro-BDNF is observed, whereas the interaction between sortilin and RAP is largely intact.