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. 2010 Feb 16;285(16):12210–12222. doi: 10.1074/jbc.M109.062364

FIGURE 6.

FIGURE 6.

Mutation of the linear binding site specifically impairs binding of both the NGF and the BDNF pro-domains. SPR analysis showing reduced binding of equal amounts (analyte concentration: 200 nm) of the soluble extracellular domains of sortilin-4A compared with sortilin-WT when binding is tested to both the immobilized BDNF pro-domain (HisS-BDNFpro, A) and the immobilized NGF pro-domain (GST-NGFpro, B).