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Inhibition of rRNA transcription and early rRNA processing, but not late rRNA processing induces nucleoplasmic translocation of NPM. A, methotrexate inhibited transcription of rRNA; B, flavopiridol early rRNA processing steps; C, 5-fluorouracil late rRNA processing steps. A panel of concentrations with increasing inhibitory activity (blue box) was analyzed in parallel for NPM translocation to the nucleoplasm and the ratio of 32 S/28 S rRNA.
