Fig. 3.

a, Clearance of unlabeled human apoE (isoform 3; 0.70 ng), non-lipidated and lipidated, from brain ISF within 30 min of administration into the caudate nucleus. ApoE was infused simultaneously with ¹⁴C-inulin. b, Clearance of native human apoJ (1.6 ng) from brain ISF within 30 min of its simultaneous administration into the caudate nucleus with ¹⁴C-inulin. c, Clearance of unlabeled Aβ40 and apoE (isoform 3) administered into brain ISF simultaneously with ¹⁴C-inulin either alone (closed bars) or in the form of Aβ- apoE complex (open bars). Inulin values not shown. ApoE, apoJ and Aβ levels were determined focally in brain and plasma by using human specific ELISAs, as described in Methods. Values are mean ± s.e.m. from 3 to 5 independent experiments.