Table 1.

Clearance rates of unlabeled Aβ, apoE and apoJ across the BBB and via the ISF flow.

Clearance rates (pmol/min/g ISF)
Non-labeled molecules	Transport via BBB	Transport via ISF
A β 40	0.211 ± 0.022	0.034 ± 0.004
A β 42	0.111 ± 0.011	0.031 ± 0.002
non-lip-apoE3	0.041 ± 0.003	0.030 ± 0.003
lip-apoE3	non-detectable	0.035 ± 0.005
apoJ	0.163 ± 0.013	0.037 ± 0.003
A β 40-apoE	0.037 ± 0.003 *	0.034 ± 0.003

Values were calculated with eqs. 2,4, and 5; Mean ± s.e.m. from 6-8 mice per test molecule.

^*p<0.01, Aβ40-apoE compared to Aβ40. Non-lip-apoE3, lipid-poor apoE3; lip-apoE3, lipidated apoE3.